PAMAM dendrimer - Names and Identifiers
PAMAM dendrimer - Physico-chemical Properties
| Molecular Formula | C22H48N10O4
|
| Molar Mass | 516.68 |
| Density | 0.854 g/mL at 25 °C |
| Boling Point | 64.7 °C |
| Flash Point | 52 °F |
| Appearance | Form 20 wt.% in methanol |
| pKa | 14.94±0.46(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | n20/D 1.364 |
PAMAM dendrimer - Risk and Safety
| Risk Codes | R11 - Highly Flammable
R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed.
R39/23/24/25 -
|
| Safety Description | S7 - Keep container tightly closed.
S16 - Keep away from sources of ignition.
S36/37 - Wear suitable protective clothing and gloves.
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
|
| UN IDs | UN 1230 3/PG 2 |
| WGK Germany | 3 |
PAMAM dendrimer - Introduction
STARBURST(R) (PAMAM) DENDRIMER, GENERATION O(PAMAM) is a polymer compound that has a branched structure, similar to the shape of a tree. Dendrimer PAMAM is commonly sold commercially under the brand STARBURST(R)(star), where O represents zero generation.
PAMAM Dendrimers have the following characteristics:
1. Multi-branched structure: PAMAM dendrimers are connected with many branches through the main chain, making it highly branched.
2. Large molecular weight: PAMAM Dendrimers have a high molecular weight, usually between thousands to hundreds of thousands of grams/mole.
3. Multifunctionality: Due to its multi-branched structure, PAMAM dendrimers can achieve various functions by introducing different functional groups on the branches.
Applications of PAMAM dendrimers include:
1. Drug delivery: PAMAM Dendrimers have good drug delivery properties and can be used as carriers of drug delivery systems to increase the stability and targeting of drugs.
2. Biosensor: PAMAM dendrimer can be used as the signal amplifier of the biosensor, which can improve the sensitivity and detection ability of the sensor.
3. Vector: PAMAM Dendrimer can be used as a carrier of DNA or RNA for gene delivery and gene therapy.
The preparation methods of PAMAM dendrimers include various methods such as chemical synthesis or nucleic acid synthesis. One of the most commonly used is the step-wise synthesis method, in which molecules are gradually grown by repeated construction and modification.
Regarding safety information, PAMAM Dendrimer is a relatively new polymer compound, and its safety has not been fully determined. However, according to existing studies, PAMAM Dendrimers are toxic to cells at certain concentrations. Therefore, when using PAMAM tree-like macromolecules, strict safety evaluation and appropriate dose control are required to ensure its safe application.
Last Update：2024-04-09 21:04:16